This study develops a micron‐sized ferroferric oxide (Fe3O4)/MXene (FM) heterojunction that scavenges extracellular ROS by activating catalase (CAT)‐like and superoxide dismutase (SOD)‐like activities, and releases ferric ions and ferrous ions to induce bacterial ferroptosis and combat bacterial infection. Here, CAT is linked to bacterial infectious disease.