The results of 4-1BB/OX-40 upregulation, CD107a upregulation, and IFN-γ/TNF-α secretion showed that TCR-001–transduced allogeneic T cells selectively recognized several human pancreatic cancer organoids with natural KRAS G12V mutation and HLA-A*11:01 expression to different degrees (Figure 5, B–D), which could be due to different levels of antigen presentation in these human pancreatic cancer organoids. This evidence concerns the gene IFNG and familial pancreatic carcinoma.