TNF and familial pancreatic carcinoma: The results of 4-1BB/OX-40 upregulation, CD107a upregulation, and IFN-γ/TNF-α secretion showed that TCR-001–transduced allogeneic T cells selectively recognized several human pancreatic cancer organoids with natural KRAS G12V mutation and HLA-A*11:01 expression to different degrees (Figure 5, B–D), which could be due to different levels of antigen presentation in these human pancreatic cancer organoids.