When comparing scores between groups adjusting for the presence of intellectual disability, only BRPF1 and KANSL1 significantly differed from the DYRK1A, KAT6A, and DDX3X groups on the Vineland‐3 domains; other statistically significant group differences were not detected between the groups, further suggesting a lack of distinct syndrome‐specific profiles beyond the level of intellectual disability. Here, KAT6A is linked to Intellectual disability.