DPP4 and diabetes mellitus: The extracts of Antidesma madagascariense Lam, whose leaf and stem bark decoctions are used in folk medicine in Madagascar for the management of DM, showed inhibitory activity against DPP-4 enzyme with an IC50 value of 79.2 mg/ml (Mahomoodally et al. 2015, Beidokhti et al. 2018).