Although our study was limited by the low number of LC patients, we present evidence of an immunological signature, specifically observed in patients with LC, compared to HD/Recovered subjects, characterized by the lower proliferative capacity of memory CD8 T cells, evaluated by Ki67 expression and lower activation markers on both memory CD8 T cells and γδ T cells, including the expression of homing and resident receptors such as CXCR5 and CCR6, respectively. Here, CXCR5 is linked to laryngotracheoesophageal cleft.