GOLM1 and neoplasm: Furthermore, exosomal GP73 can directly regulate the signaling pathways of tumor cells through an autocrine manner to promote their growth and metastasis (96), or enter the vascular endothelial cells and bind to the functional proteins through its coiled-coil domain to suppress their functions (22), thereby regulating the intracellular signaling pathways and promoting angiogenesis in the tumor microenvironment.