Since early studies have demonstrated that GP73, by promoting the membrane transportation and extracellular secretion of EMT-related proteins, can facilitate tumor metastasis (27–29), thus, we have hypothesized that GP73, as a transport protein, can also modulate the transport and secretion of cytokines and chemokines, thereby remodeling the tumor microenvironment. The gene discussed is GOLM1; the disease is neoplasm.