Compared with healthy subjects, IPF sufferers had higher concentrations of IL-22 when compared to healthy subjects (8.1 pg/ml vs 3.35 pg/ml; p=0.003 before vaccination; 11.04 pg/ml vs 3.72 pg/ml; p=0.01 after the 1st dose; 12.73 pg/ml vs 3.74 pg/ml; p=0.0016 after the 2nd dose). The gene discussed is IL22; the disease is idiopathic pulmonary fibrosis.