IPF patients without prior exposure to SARS-CoV-2 exhibited higher concentrations of IL-6 when compared to healthy individuals before (3.93 pg/ml vs 1.84 pg/ml; p=0.016) and after vaccination (3.93 pg/ml vs 1.35 pg/ml; p<0.000 after the 1st dose; 5.04 pg/ml vs 1.35 pg/ml; p<0.000 after the 2nd dose]. Here, IL6 is linked to idiopathic pulmonary fibrosis.