ELN and neoplasm: In solid tumors, the tumor parenchyma is usually surrounded by an aberrantly organized ECM made of overexpressed components that contain variable proportions of fibrous proteins (collagen, fibronectin, laminin, and elastin), as well as, GAGs (hyaluronic acid (HA)), and PGs (chondroitin sulfate and heparan sulfate) (8, 30).