CD4 and melanoma: For instance, intratumoral injection of an oncolytic adenovirus armed with therapeutic transgenes for PH20, IL-12, and sPD1-Fc (KLS3020) resulted in increased tumoral infiltration of CD4+ and CD8+ T cells, intratumoral populations of IFN-γ+ effector CD4+ and CD8+ T cells, and enhanced the Teff/Treg ratios of tumoral TILs in animal models of melanoma and colorectal carcinoma (71).