For instance, treatment with an engineered OX40-L expressing oncolytic herpes simplex virus-1 (OV-mOX40L) in a KPC syngeneic model of pancreatic carcinoma effectively remodeled the desmoplastic tumor ECM by increasing the number of iCAFs and decreasing the number of myCAFs (93). This evidence concerns the gene TNFSF4 and neoplasm.