For instance, an oncolytic adenovirus carrying a therapeutic gene for the anti-fibrotic hormone relaxin (RLX) and genes for immunomodulatory cytokines IL-12 and GM-CSF (oAd/IL12/GM-RLX) increased the intratumoral infiltration of activated CD4+, IFN-γ+ and CD8+, IFN-γ+ T cells in a Syrian hamster model of pancreatic cancer (77). This evidence concerns the gene CD8A and familial pancreatic carcinoma.