Another relaxin-expressing oncolytic adenovirus (oAd/IL12/GM-RLX), armed with interleukin 12 (IL-12) and granulocyte-macrophage colony stimulating factor (GM-CSF), demonstrated the capacity to promote ECM degradation, facilitating the infiltration of activated and exhausted tumor antigen-reactive CD8+ T cells and enhancing the efficacy of ICB in refractory tumors (77). This evidence concerns the gene CSF2 and neoplasm.