Conversely, CD39-expressing Tregs identify a subpopulation of Tregs with enhanced suppressive capacities due to the ATPase activity of this membrane protein (47) and that was found to be increased over time since the start of symptoms in our ALS cohort, especially when the ALSFRS-r score did not decrease as expected. The gene discussed is DNAH8; the disease is amyotrophic lateral sclerosis.