Furthermore, the characterization of Treg phenotypic activity through the analysis of surface marker expression has offered the opportunity to better explain some of the variations in Tregs during the course of ALS since the onset of symptoms and has shed light on PD1+ and CD39+Tregs, which tend to vary and positively correlate with markers of neurodegeneration. The gene discussed is ENTPD1; the disease is amyotrophic lateral sclerosis.