The results revealed that SIRT1 was significantly different in different immune subtypes of 16 cancer types, including BLCA (5 subtypes), BRCA (5 subtypes), GBM (3 subtypes), HNSC (5 subtypes), KIRC (6 subtypes), LGG (4 subtypes), LIHC (5 subtypes), LUAD (5 subtypes), LUSC (5 subtypes), OV (4 types) subtypes), PAAD (5 subtypes), PRAD (4 subtypes), SARC (5 subtypes), SKCM (5 subtypes), TGCT (4 subtypes), and UCEC (5 subtypes) (Figures 5A-P). Here, SIRT1 is linked to cancer.