RLIG1 and cancer: Rlig1 is an RNA ligase that covalently joins 5′-phosphates to 3′-hydroxyl ends.5,6 Previous research has demonstrated that Rlig1-deficient cells exhibit increased sensitivity to ROS.5 Dysregulated ROS levels are implicated in the development of several diseases, including neurodegenerative disorders and cancer.17–26 Understanding the biological role of Rlig1 in this context is therefore crucial.