TTR and heart disorder: To further refine the study and capture research hotspots, the top 11 keyword clusters were divided into 2 sections: heart disease (#0 short qt syndrome, #2arrhythmogenic cardiomyopathy, #5 hypertrophic cardiomyopathy, and #10 familial hypercholesterolemia), and diagnosis and therapy (#1 ion channels, #3 genetic testing, and #4 desmosome, #6 guidelines, #7 torsade de points, #8 transthyretin, and #9 exome sequencing).