TNFSF10 and colorectal cancer: Moreover, recent studies have also confirmed that the oral administration of Lactobacillus casei ATCC 393 can significantly inhibit the growth of colorectal cancer cells by a mechanism that could lead to the upregulation of TNF-related apoptosis-inducing ligand (TRAIL) and the downregulation of survivin, a key effector molecule involved in the process of cellular apoptosis (Ghorbani et al., 2022).