GPX4 and lymphoma: Recent evidence suggests (Liu et al., 2021) that lymphoma cells reliant on lipoprotein-mediated cholesterol uptake also undergo iron mediated death—a mechanism of cell demise dependent on oxygen and iron—triggered by the accumulation of oxidized lipids within the cellular membrane unless glutathione peroxidase 4 (GPX4), an enzyme responsible for reducing these toxic lipids (Forcina and Dixon, 2019), intervenes.