Another study based on T2DM patients also found that QWBZS granules significantly reduced the levels of inflammatory factors, improved insulin resistance, lowered blood glucose, and improved the clinical symptoms and Chinese medicine symptom scores of patients with spleen deficiency pattern T2DM by inhibiting the TLR4/NF-κB signaling pathway (Wang, 2023). This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.