ITGAX and cerebral amyloid angiopathy: Additionally, ITGAX plays a role in inflammatory pathways in chronic kidney disease, ulcerative colitis (Liang et al., 2023), and neurodegenerative diseases like Alzheimer’s disease and cerebral amyloid angiopathy, where its overexpression in microglia contributes to neuroinflammation (Lopes et al., 2024).