BDNF and epilepsy: In the pilocarpine rat model, however, there was an acetylation upsurge at the brain-derived neurotrophic factor (BDNF) promoter after SE (Huang et al., 2002), and induction of c-fos through epileptic processes implies the role of acetylation in controlling mechanisms involved in epilepsy development (Sng et al., 2006).