TSC1 and TSC2 proteins form a complex that inhibits mTOR activity; therefore, deletion of these proteins causes hyperactive mTOR signaling, intellectual impairment, refractory epilepsy, intellectual impairment, and an autistic-like phenotype (Chu-Shore et al., 2010; Vignoli et al., 2015). Here, TSC1 is linked to Cognitive impairment.