The lack of an observed impact of TBI on Alzheimer’s disease pathology aligns with findings from a previous study using ADNI DOD data.48 In that study, no significant increases were detected in Aβ ([18F]florbetaben, Centiloid; global neocortex), tau ([18F]flortaucipir, SUVR; global neocortex as well as three composites, i.e. mesial-temporal, temporo-parietal, and rest of the neocortex) or glucose metabolism ([18F]FDG, SUVR; global neocortex, frontal composite, mesial-temporal, posterior cortical regions). This evidence concerns the gene MAPT and Alzheimer disease.