MAPT and early-onset autosomal dominant Alzheimer disease: There is a well-established connection between Aβ and hyperphosphorylated tau in the context of cognitive aging and Alzheimer’s disease.11 Notably, it is widely understood that Aβ drives the accumulation of tau in the neocortex, with both protein aggregates demonstrating a distinct spreading pattern.11,22,23 Therefore, a logical next step was to assess whether a history of TBI might influence the relationship between Aβ and tau.