MAPT and early-onset autosomal dominant Alzheimer disease: Moreover, we showed that TBI might be associated with a decoupling between established Aβ and tau relationships in early Alzheimer’s disease–susceptible brain regions, and with a tighter link between the two proteins in brain regions less specific to Alzheimer’s disease but more commonly linked to TBI.13 Future studies should seek to validate and replicate these findings in larger cohorts using a longitudinal design, ideally encompassing both male and female participants.