However, they can also be linked to axonal degeneration associated with cortical Alzheimer’s disease pathology (i.e. deposition of amyloid-beta and hyperphosphorylated tau).82,83 The biochemical profile of WMHs in posterior parietal regions has been shown to differ between individuals with and without Alzheimer’s disease dementia. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.