COL11A1 and rectum adenocarcinoma: This observation aligns with a study [20] analyzing the TCGA colorectal cancer dataset, which reported a notable increase in COL11A1 mRNA expression across various cancer subtypes, including colon adenocarcinoma, colon mucinous adenocarcinoma, rectal adenocarcinoma, and cecal adenocarcinoma, when compared to normal colon tissues.