Numerous studies have attempted to explain the mechanisms of physical exercise against cancer, and several targets, such as interleukin-15 (IL-15) and squalene epoxidase (SQLE), have been revealed [7,14], but it has been uncovered that physical activity participates in the reprogramming of the tumor microenvironment (TME) [15,16]. The gene discussed is SQLE; the disease is cancer.