PCBP1 and head and neck cancer: Failure of the iron and RNA-binding activity of PCBP1 and inhibition of PCBP1 allows cells to perceive a lack of cellular iron and leads to an inadequate supply of iron to syncytia that require iron to function properly (4, 5).It has been shown that PCBP1 plays an important role in ferritin phagocytosis-mediated iron mutations in head and neck cancer cells, and PCBP1 also regulates the translation of ALOX15 by binding to the 3′-UTR regional regulatory complex that controls the assembly of 80s ribosomal subunits (6).