Arachidonate-15-Lipoxygenase (ALOX15) plays a central role in lipid peroxidation and ferroptosis (2), and carbon ion rays lead to DNA double-stranded damage in tumor cells, as well as inducing changes in tumor metabolism factors, which damage nucleic acids, proteins and lipids and cause cellular damage and even death (3). The gene discussed is ALOX15; the disease is neoplasm.