In a pre-clinical rat MI model where MI was induced with left anterior descending (LAD) coronary artery ligation, curcumin through the inhibition of p38 MAPK and JNK and activation of RISK/GSK-3β protected against myocardial ischemia/reperfusion injury (Jeong et al., 2012). Here, MAPK8 is linked to myocardial infarction.