CD274 and neoplasm: Gonadotrophs tumors have less tumor-infiltrating lymphocytes (Wang et al., 2018; Mei et al., 2016) and fewer genomic alterations (Song et al., 2016): those findings may suggest that these tumors might not respond favorably to immunotherapies including PD-1/PD-L1 inhibitors (Ilie and Raverot, 2020).