Inflammation associated with obesity is primarily caused by excess nutrients that activate the signaling pathways localized in adipose tissue triggering inflammatory responses resulting in the increased secretion of cytokines such as IL-6, TNF-α, IL-17, and IL-23; c-JNK; and NF-κB [29]. This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.