AKT1 and cancer: Weight-reducing strategies as well as consuming flavonoids-phenol-rich natural foods known to have chemopreventive properties in targeting phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and Wnt-beta-catenin signaling pathways are strategic interventions as a key component of cancer treatment and prevention. Natural therapies with phenol-rich plant products reduce the adverse side effects of cancer treatment seen with chemotherapy drugs [21].