This research focused on its impact on (1) lipid parameters, including total cholesterol, triglycerides (TG), high-density lipoproteins (HDL), and low-density lipoproteins (LDL); (2) the formation of aberrant crypt foci (ACF) in the colon; (3) the expression of CRC tumor markers, specifically beta-catenin and Ki67; (4) the levels of pro-inflammatory cytokines such as leptin, IL-6, IL-12p70, and TNF-α; and (4) the activation of the NF-κB inflammatory pathway, which are frequently observed in CRC rat models. The gene discussed is LEP; the disease is colorectal carcinoma.