NT4 binding to human cancer cell lines resulted in either inhibition or increase of oriented migration in PANC-1 human pancreas adenocarcinoma and TE671 human rhabdomyosarcoma cancer cells, respectively, indicating a crucial but diverse role of HSPGs in oriented cell migration in different cancer cells (Depau et al., 2020). The gene discussed is NTF4; the disease is pancreatic adenocarcinoma.