SHBG and polycystic ovary syndrome: The administration of prebiotics and probiotics in women diagnosed with PCOS has been shown to enhance lipid metabolism, as well as hormonal parameters, including the Free Androgen Index and sex hormone-binding globulin, and inflammatory markers such as nitric oxide and malondialdehyde (Shamasbi et al., 2020; Giampaolino et al., 2021).