Vallejo et al. (2014) showed that in Lagovirus europaeus/GI.1 infection there is increased expression of phospho-mTOR in the liver at 12, 18, and 24 h p.i., which unexpectedly correlated with the simultaneous development of autophagy. These results indicated that mTOR was not a negative regulator of autophagic flux. Given that our study achieved down-regulation of autophagy genes (Beclin-1, Atg5, Atg12, Atg16L, and MAP1LC3B) in blood cells during the initial phase of infection, further work will be required to determine the involvement of mTOR signaling in this phenomenon. This evidence concerns the gene ATG16L1 and infection.