The catabolites of prostaglandin E2 (PGE2), including 15-keto-PGE2 and 8-iso-15-keto-PGE2, have been shown to alleviate hepatic inflammation in diet-induced obesity mouse model, indicative of lower activities of ALT and aspartate transferase and inhibited macrophage infiltration (Hee et al., 2023). Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.