However, it has also been reported that icariin can up-regulate the expression of SIRT6 protein and deacetylates H3K9 on the promoter of the NF-κB target gene to induce apoptosis and inhibit tumor cell metastasis via SIRT6/NF-κB in triple-negative breast cancer [20]. This evidence concerns the gene NFKB1 and neoplasm.