Additionally, we uncovered the contributions of ncRNAs such as LINC00487, LINC00968, LINC01004, LINC01260, MIR223, LINC00641, and LINC01619 in modulating interferon-driven inflammation and disease progression, offering a fresh perspective on non-coding elements in SLE. This evidence concerns the gene KMT2E-AS1 and systemic lupus erythematosus.