KEGG analysis of B-cells, including the full dataset and subsets of activated naïve B cells and antigen-secreting cells, identified several key pathways including “chemokine signaling pathway”, “cytokine-cytokine receptor interaction”, “complement and coagulation cascades”, “systemic lupus erythematosus”, “NF-kappa B signaling pathway”, “TNF signaling pathway”, “JAK-STAT signaling pathway”, and “FoxO signaling pathway”. Here, TNF is linked to systemic lupus erythematosus.