The dopaminergic signaling pathway was upregulated through exercise training in different animal strains of Parkinson’s disease, which increased striatal tyrosine hydroxylase (TH) protein expression and dopamine (DA) levels (Minakaki et al., 2019; Rezaee et al., 2020; Tsai et al., 2019; Koo et al., 2017a; Dutta et al., 2022; Fallah Mohammadi et al., 2019; Goes et al., 2014). The gene discussed is TH; the disease is Parkinson disease.