Treadmill training for 8 weeks induced neuroprotection of the nigrostriatum against MPTP-induced cell death by suppressing neuronal apoptosis, decreasing BAX expression, and increasing Bcl-2 expression and cleaved caspase-3 in PD animal model (Chul et al., 2018; Koo et al., 2017a). Here, CASP3 is linked to Parkinson disease.