CASP1 and Parkinsonism: Furthermore, treadmill training 5 days per week for 6 weeks reduced the inflammasome (NLRP3), a large macromolecular complex that contains multiple copies of DAMP receptors, pro-caspase-1, and an adaptor called ASC (apoptotic speck containing protein with a CARD), inhibited the maturation of caspase-1, and inhibited cell death in the substantia nigra of MPTP-induced Parkinson’s mice (Wang et al., 2021).