BCL2 and Parkinson disease: The apoptotic pathway is a critical pathway upregulated in Parkinson’s disease, where damage-associated molecular patterns (DAMPs) increase apoptosis by limiting anti-apoptotic protein Bcl-2 and increasing pro-apoptotic proteins Bcl-xl in the MPTP-induced PD animal model (Chul et al., 2018; Akhtar et al., 2004).