Another non-synonymous variant of unknown significance in the LYST gene (p.A1683V), which is autosomal recessive monogenic gene for systemic inflammatory syndrome (Schulert et al., 2016), and a potential combination of heterozygous mutations in LYST in children with viral infection can lead to MIS-C (Vagrecha et al., 2022). Here, LYST is linked to viral infectious disease.