CPN1 and liver disorder: The mean level of antibodies directed against bacterial antigens in sera of patients with PBC was also elevated than in other liver diseases with a significant difference: 80 ± 44 vs. 62 ± 15 RU/ml, p < 0.0001 for anti-Cpn; 60 ± 22 vs. 45 ± 26 RU/ml, p < 0.0001for anti-Hp; 36 ± 30 vs. 26 ± 7 RU/ml; p = 0.059 for anti- M. pneumoniae, 59 ± 50 vs. 41 ± 20 RU/ml, p < 0.0001 for anti- Y. enterolitica and 6.8 ± 2.6 vs. 4.9 ± 1.7 units/ml, p < 0.0001 for anti-E.coli (Supplementary Figures 1-5).