Primary biliary cholangitis (PBC) is a cholestatic, autoimmune liver disease, characterized by the existence of anti-mitochondrial (AMA) and antinuclear antibodies like anti-gp210 and anti-Sp100 in the patients’ sera (Ma et al., 2017; Bauer et al., 2021; Granito et al., 2021; You et al., 2022; Trivella et al., 2023; Wang et al., 2023; Xu et al., 2023; Wang et al., 2024). Here, SP100 is linked to primary biliary cholangitis.