TGFB1 and neoplasm: These anti-tumor activities are linked to the suppression of key signaling pathways, such as Nrf2 and Transforming Growth Factor β (TGF-β), as well as the TGF-β/protein kinase C/Mitogen-Activated Protein Kinase/Matrix Metalloproteinases (MAPK/MMP) pathway [24, 26, 27].