TFNα, IL-1β, IL-6, and IL-8 are responsible for atherogenesis; especially TFNα is related to CVD and atherogenesis; IL-6 is related to thrombocytosis; IL-8 related with plaque formation; IL-1β related with vascular inflammation and correlate with atherogenesis. Here, IL1B is linked to thrombocytosis disease.