Only four CRC-related genes (BIRC5, PIK3CD, RALGDS, and TGFB1) showed statistically significant methylation differences between racial groups, and the differences were substantially less than the differences noted for the previously identified top six genes (APOL3, MFAP2, etc.), except for TGFB1. This may suggest that in our racial/ethnic minority cohort, EOCRC disparities may be related more to auxiliary risk factors, such as metabolism, diet, and immune function, than to canonical CRC pathways. This evidence concerns the gene PIK3CD and colorectal carcinoma.