Furthermore, while crossing the ApoeCh mice with amyloidosis and tauopathy models in parallel provides important insights into how the variant independently affects Aβ plaques and tau, it is important to investigate the effect of the ApoeCh variant in a mouse model that develops both Aβ and tau pathologies in an age appropriate manner, ideally not produced via classical transgenes. The gene discussed is MAPT; the disease is amyloidosis.