In microglia, we observed a significant reduction in DAM-related proteins (i.e., CD11c, CD68, TYROBP) in PS19;ApoeCh compared to PS19, indicating that microglia have a reduced response to tauopathy in the presence of ApoeCh. The reduction in CD68 whole-brain coverage in 5xFAD;ApoeCh vs 5xFAD mice was independently supported via immunostaining for CD68 (Supp. Here, CD68 is linked to tauopathy.