Similarly, the three OFC subtypes displayed uneven geographical distributions within Switzerland (Fig. 3A): Ticino had the highest prevalence per 10,000 LB of both CP (6; 95% CI: 3.26–8.74; corresponding to 1:1,667 newborns) and CL (3.59; 95% CI: 1.05–6.13; corresponding to 1:2,786 newborns), while CLP was most frequently observed in Central Switzerland (6.27; 95% CI: 5.19–7.35; corresponding to 1:1,595 newborns). This evidence concerns the gene CP and otofaciocervical syndrome 1.