Furthermore, a Kaplan-Meier survival analysis shows poor OS for those exhibiting increased cytoplasmic expression of PURα compared with those with low cytoplasmic expression of PURα in a large cohort (526 ESCC cases), indicating PURα as a potential prognostic biomarker for ESCC (Tian et al. 2022). Here, PURA is linked to esophageal squamous cell carcinoma.