PURA and pachyonychia congenita: Later, PURα has been identified as a potential tumor suppressor in several cancer types, including glioblastoma (GBM), prostate cancer (PC), and breast cancer (BC) (Adema et al. 2022; Darbinian et al. 2001; Inoue et al. 2008; Yu et al. 2023; Wang et al. 2008).