To ascertain that our findings were not spurious, public domain GDC TCGA Breast Cancer (BRCA) database was consulted and elevated TWF1 mRNA expression did show a trend toward poor overall survival (Supplementary Fig. 1) while PIK3CA alterations did impact ANXA6 mRNA expression (Supplementary Fig. 2) [47]. This evidence concerns the gene ANXA6 and breast cancer.