Using a slightly different 12 h night time TRF approach, Niu et al. showed similar positive effects, which were dependent on a functional clock, as no improvements were observed after TRF in Bmal-1IEC−/−xIL-10−/− double knockout mice.12 Combined, these two studies provide strong evidence that TRF can compensate to some extent for the disruptive effects of IL-10 deficiency on intestinal clock and experimental colitis. This evidence concerns the gene IL10 and colitis.