CLOCK and colitis: To characterize the influence of clock disruption on the onset of experimental colitis in IL-10 deficient mice, 8-week-old IL-10-/- and WT mice from different litters were co-housed in groups of 4–5 mice per cage for 2 weeks and subsequently exposed to 12 weeks of altered (4 h/4 h) light/dark cycles (E.2, Figure 2a).