IL10 and colitis: Ad libitum (AL)-fed IL-10-/- mice exposed to altered light/dark cycles from E.2 but not E.3 developed experimental colitis earlier than IL-10-/- mice under normal light/dark conditions (Figure 2c) and displayed increased colonic inflammation in histological scores (immune cell infiltration, tissue damage, bowel wall thickness) and gene expression levels of the proinflammatory cytokine TNF-ɑ, chemokine ligand (CCL)-5 and interferon (IFN)-ɣ (Figure 2d, Suppl.