MSH2 and Lynch syndrome: Pathogenic variants within Lynch syndrome genes (EPCAM, MLH1, MSH2, MSH6 and PMS2) were the next most common within our analysed MINAS cohort at 21.8% (90/413), with MSH2 PVs being the most common (7.5%; 31/413) and EPCAM PVs are the least common (0.8%; 3/413).