In testing the impact of p53 on long-term MHV68 latency, we found that viral genome-positive cells in spleens of p53-/- mice were ca. 5-fold lower than WT mice on day 42 post-infection, a phenotype that was maintained up to 100 days post-infection (Supplementary Fig. 8a, b). The gene discussed is TP53; the disease is infection.