Together, these data show that depletion of CD11c+ cells (including pDCs, cDC1s, CD301b+cDC2s and AlvMΦs) reduces eosinophilia, and both type 2 and type 17 cytokine production by CD4+ T cells, in the pulmonary response to Af spores. Here, ITGAX is linked to Increased total eosinophil count.