Due to the central role of adipocytes in aging and obesity-related metabolic dysfunction, and their high FABP4 abundance (Matarese and Bernlohr, 1988), we investigated the dynamics of SARS-CoV-2 infection using two infection titers (MOI = 0.1 or 1, SARS-CoV-2 WA1/2020), in the human Telomerase Reverse Transcriptase (hTERT) immortalized preadipocyte cell lines (Lee et al, 2004), before and after differentiation. Here, FABP4 is linked to obesity due to melanocortin 4 receptor deficiency.