FN3K and cancer: Downregulation of FN3K in the liver (HepG2, Huh1 cell lines) and lung (H3255, H460 cell lines) cancer cell lines resulted in the impairment of NRF2 function by reducing its protein stability and disrupting its dimerization with the small musculoaponeurotic fibrosarcoma (sMAF) proteins, all of which are critical for NRF2 function29–31.