To investigate the role of ALOX15B in psoriasis, keratinocytes in vitro were treated with a cocktail of IL-17A, interferon (IFN)γ and tumour necrosis factor (TNF)α to induce a psoriasis-like phenotype following 72 h of transfection with control or ALOX15B siRNA. The gene discussed is IL17A; the disease is psoriasis.