Interestingly however, magnetic resonance spectroscopy in tPA-treated stroke patients who exhibited hyperperfused peri-lesional tissue one day after stroke – which associated with better 3-month outcome – revealed a metabolic signature that suggested increased cellular activity.30 In patient studies, it remains unclear if hyperperfused post-ischemic tissue proceeds to infarction or recovery because subacute or chronic time points are typically not included. Here, PLAT is linked to infarction.