Compared with IDH-wildtype glioblastoma, we noted higher frequencies of TP53 (P < .001), ATRX (P < .001), and PDGFRA (P < .001) mutations, and lower frequencies of alterations notably in PTEN (P = .003), NF1 (P = .375), and EGFR (P = .001) (Figure 3B). The gene discussed is PTEN; the disease is glioblastoma.