CDK6 and childhood neoplasm: In fact, CDK6 has recently been reported as a vulnerability in interneuron lineage progenitors which have been proposed to give rise H3 G34-mutant diffuse hemispheric glioma.31 In contrast to a large pediatric study that reported frequent FBXW7 mutations,32 we observed only one FBXW7 mutation, in a 17-year old patient, suggesting a link of this mutation to pediatric tumors.