Compared with a reference cohort of 50 patients with IDH-wildtype glioblastoma (reference cohort 2), diffuse hemispheric gliomas, H3 G34-mutant were characterized by less edema (P < .001), fewer satellite lesions (P = .039), smaller tumor size (P = .013), less avid contrast enhancement (P < .001), lower frequency of necrosis (P < .001), but numerically more frequent parietal location (P = .239) and deep white matter invasion (P = .038) (Supplementary Table S3, Figure 1B). This evidence concerns the gene IDH1 and glioblastoma.